Basic Science Research Fellowship

Trainees who desire basic science research training beyond that allowed in the residency program can apply for a fellowship in basic science research. This year long program may be completed before or after clinical anesthesiology training.

The Basic Science Research Fellow works in the NIH-funded Zhang Neuroscience lab, as part of the Anesthesiology Department. This allows close collaboration in exciting projects that share a focus on near-term translation potential. The Zhang lab has a number of NIH grants that provide ongoing research support:

  • R01 NS043338-06 Zhang (PI) 12/01/10 – 11/30/15
    • Mechanisms of Hyperbaric Oxygen Induced Brain Protection
    • The major objectives of this project are to establish the mechanisms of hypoxia-inducible factor and its pathways in focal cerebral ischemia and their response to oxygen treatment.

  • R01 NS078755 Zhang (PI) 12/1/12 – 11/30/17
    • Harnessing Germinal Matrix Hemorrhage
    • The major goal of this project is to establish the mechanisms of neonatal germinal matrix hemorrhage and potential treatment options.

  • R01 NS081740 Zhang (PI) 06/01/13 – 05/31/18
    • Neurovascular Protection for Early Brain Injury after SAH
    • The major goal of this project is to establish intronasal application and mechanisms to reduce neurovascular injury after subarachnoid hemorrhage.

  • P01 NS082184 Zhang (PI) 01/01/14 – 12/31/18
    • Center for Brain Hemorrhage Research
    • The major goal of this program project grant is to establish a center to study brain hemorrhages including subarachnoid and intracerebral hemorrhages and traumatic brain injury, seen in neurosurgery practice. Vertical and horizontal comparison of common and distinct features of these three brain hemorrhagic disorders will be conducted.

  • R01 NS084921 Zhang (PI) 08/01/14 – 07/30/19
    • Crotalus Snake Venom Preconditioning to Prevent Surgical Brain Injury
    • The major objectives of this project are to establish mechanisms and translation of snake venom induced preconditioning to reduce intraoperative hemorrhage and post-surgery brain edema.

The lab is dedicated to studying treatments that have the potential for translation to human treatment in the areas of outcome following ischemic stroke, global cerebral ischemia including hypoxia-ischemia, neonatal hypoxia, surgical brain injury (edema and bleeding) and cardiac arrest.

The Basic Science Research Fellow works directly with research mentors, initially learning the various techniques used for our projects by joining an ongoing study. However, from the start of the training year the Fellow develops one or more new studies in one of the Zhang lab study areas. Study completion, abstract submission and eventual publication are expectations for the Basic Science Research Fellow. Previous Fellows have published many papers as a result of their work in the lab.

Educational Objectives:
1. Basic knowledge acquisition of the physiology and pathophysiology of the brain – cerebral blood flow, cerebral edema / cell death, pathways involved in cerebral damage following injury by hypoxia, ischemia, surgery or hemorrhage
2. Research knowledge acquisition related to the techniques used in the lab such as monitoring and surgical techniques, neurobehavioral testing, etc
3. Academic knowledge of experimental design, trouble shooting of experiments, data collection and analysis, presentations and manuscript writing.

Applicant Requirements:
1. MD or PhD in biology

The Anesthesia Research Fellowship is directed by Richard Applegate II, MD. Candidates interested in this position should contact the coordinator, Audrey Romero.